ADVANCE GLYCATION END PRODUCTS (AGEs) & CELL DAMAGE
AGEs (Advanced Glycation End-products) are molecules that form in the body as a result of a chemical reaction between sugars and proteins or fats. High levels of AGEs have been linked to aging and age-related diseases such as diabetes, Alzheimer's, and cardiovascular disease. AGEs can accumulate over time and contribute to cellular damage, inflammation, and oxidative stress, which can lead to various health issues.
When we consume too much sugar, the excess sugar combines with proteins in our body to form AGEs. These AGEs not only cause skin ageing but also damage our cells and organs, affecting their functions.
Diabetes and AGEs
Everybody is subjected to AGEs formation. Accumulation of AGEs is reported as young as the age of 20 years and appears to increase steadily subsequently. People who have high blood sugar levels, such as those with diabetes or prediabetic, are at a higher risk of producing too many AGEs, which can then build up in the body.
Tips to reduce AGEs levels
DIET: Reduce our sugar intake
SUPPLEMENT: Natural antioxidants, like black turmeric, can reduce the negative health effects of AGEs
EXERCISE: Regular exercise has been proven to reduce AGEs formation
SIRT1 and how it prolongs life
Another longevity key is activating newly discovered protective genes called sirtuins, descendants of an ancient survival circuit that is both the cause of aging and the key to reversing it. Sirtuins can be switched on both by lifestyle changes such as intermittent fasting, as well as by consuming ingestibles that boost NAD+ (nicotinamide adenine dinucleotide), a chemical that's central to how the metabolism functions. One particular sirtuins, is known as SIRT1 (also called “the longevity gene”). SIRT1 “recharges” mitochondria — the “power plants” of the cells — which tend to wind down with age. Therefore, any substance that can enhance the SIRT1 gene pathway is of great interest to anti-aging researchers.
The SIRT1 protein drives many cellular activities, like energy metabolism, cell survival, DNA stability, inflammation and circadian rhythms.
SIRT1 is also known to suppress inflammation and increase resistance to hypoxia (oxygen deprivation) and heat stress.
Cell and experimental studies demonstrate that SIRT1 activation is associated with increased insulin sensitivity. It has been shown – in experimental studies – to play a vital role in processes that could potentially prevent many age-related diseases, including Type 2 diabetes, neurodegeneration, Alzheimer’s disease and cancer. Resveratrol is well-known for this effect. Now, there’s another natural ingredient that works in the same way, but is five times more potent.
How black turmeric helps
Derived from the rhizome of black turmeric (Kaempferia parviflora) and rich in polymethoxyflavonoids (PMFs), our patented ingredient could be the AGEs-reversing component you’re looking for. Recent researches indicate that it helps to activate our longevity genes1 and improve metabolic conditions.
A double-blind, placebo-controlled human study with 27 subjects found that taking 100 mg of black turmeric extract daily for seven weeks, helps to:
Caused a reduction in body weight
Helped maintain blood sugar levels within a normal range
Decreased the production of advanced glycation end products (AGEs)2
Showed a trend toward improvement in blood circulation
1. Zhang M et al. “Quercetin 3,5,7,3′,4′-pentamethyl ether from Kaempferia parviflora directly and effectively activates human SIRT1.” Communications Biology, vol. 4 (2021)
2. Yagi M, Tateiwa Y, Inoue K, Sato Y, Takabe W, Ishizaki K, Yonei Y. Antiglycative effect of Kaempferia parviflora Wall. Ex. Baker (Zingiberaceae): Prevention of advanced glycation end product formation. Glycative Stress Research. 2018;5(4):163.
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